Research Journal of Pharmaceutical Dosage Form and Technology

Shilpa N. Shrotriya ¹, Kishore N. Gujar ¹, Bhakti R. Chorghe ²

Affiliations
1 Department of Pharmaceutics, Sinhgad College of Pharmacy, Vadgaon (Bk.), Pune – 411 041, Maharashtra, IN
2 Sinhgad College of Pharmacy, Vadgaon (Bk.), Pune – 411 041, IN

Abstract

The objective of the present investigation was to formulate and evaluate unidirectional, bilayered, buccoadhesive tablets of rasagiline mesylate using natural excipients. Caesalpinia pulcherrima polysaccharide (CSP), Tamarind seed polysaccharide (TSP) and Locust bean gum (LBG) were used as mucoadhesive agents in the formulation. The polysaccharides were isolated and were characterized for physicochemical properties such as solubility, pH, viscosity, test for carbohydrates, flow properties, microbial load, disintegration and swelling index. Differential scanning calorimetric (DSC) studies revealed that the polysaccharides were physically compatible with drug, rasagiline mesylate (RM). The formulation F12 containing CSP (15 mg), LBG (30 mg), TSP (30 mg) demonstrated bioadhesion force of 0.3941 ± 0.01 N, residence time of 120 ± 0.3 min, % drug release of 92.81 ± 0.2% and % drug diffusion of 92.01 ± 0.01% was selected as the optimized formulation. Thus, this study suggests that CSP, TSP and LBG in combination can act as potential mucoadhesive agents for buccal delivery.

Keywords

Buccal Tablet, Caesalpinia Pulcherrima Polysaccharide, Tamarind Seed Polysaccharide, Locust Bean Gum, Rasagiline Mesylate, Mucoadhesion.

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Swapnil T. Deshpande ¹, P. S. Vishwe ², Rohit D. Shah ³, Swati S. Korabu ³, Bhakti R. Chorghe ³, D. G. Baheti ²

Affiliations
1 Sitabai Thite College of Pharmacy, Shirur, Pune – 412 210, IN
2 SCSSS’s Sitabai Thite College of Pharmacy, Shirur, Pune – 412 210, IN
3 Sinhgad College of Pharmacy, Vadgaon (Bk.), Pune – 411 041, IN

Abstract

Diabetes is chronic metabolic disorder, resulting from insulin deficiency, characterized by hyperglycaemia, altered metabolism of carbohydrate, protein and lipids and an increased risk of vascular complication. The disadvantage of antidiabetic drugs such as more frequent of administration, extensive first passes metabolism and variable bioavailability, makes it is an ideal candidate for transdermal drug delivery systems. This article is dedicated to the review of antihypertensive transdermal patches in the perspective of enhancing the bioavailability as well as in improving the patient compliance. The various antidiabetic drugs sulfonylurea's (SU), biguanides, meglitinide, thiazolidinediones (TZDs) Currently a number of antidiabetic transdermal patches are introduced in to the pharmaceutical market. Most of the reported methods in the literature employed solvent evaporation method or solvent casting method for the preparation of transdermal patches. Depending on the release required over a period of time, the concentrations of polymer, plasticizer and penetrant were varied.

Keywords

Antidiabetic Drugs, Diabetes, Transdermal Drug Delivery Systems, Transdermal Patches.

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Bhakti R. Chorghe ¹, Swapnil T. Deshpande ², Rohit D. Shah ¹, Swati S. Korabu ¹, Sagar V. Motarwar ³

Affiliations
1 Sinhgad College of Pharmacy, Vadgaon (Bk.), Pune – 411 041, IN
2 SCSSS’s Sitabai Thite College of Pharmacy, Shirur, Pune–412 210, IN
3 Smt. Kashibai Navale College of Pharmacy, Kondhwa (Bk.), Pune – 411 048, IN

Abstract

Transdermal therapeutic systems, or transdermal patches, facilitate controlled release of active ingredients through the skin and into the systemic circulation. Drugs administered through such systems escape first pass metabolism and steady state is maintained similar to a continuous intravenous infusion for up to several days. The transdermal route of drug delivery has attracted researchers due to many biomedical advantages associated with it. However, excellent impervious nature of skin is the greatest challenge that has to be overcome for successfully delivering drug molecules to the systemic circulation by this route. This article gives a brief overview over principles behind transdermal drug delivery, as well as the advantages and disadvantages of transdermal therapeutic systems and the recent innovations in the field of transdermal drug delivery and also describes the methods of preparation of different types of transdermal patches, evaluation parameters and some available marketed products.

Keywords

Transdermal Drug Delivery System, Transdermal Patches, Evaluation of Transdermal System, Skin.

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Swapnil T. Deshpande ¹, P. S. Vishwe ², Rohit D. Shah ³, Swati S. Korabu ³, Bhakti R. Chorghe ³, D. G. Baheti ²

Affiliations
1 Sitabai Thite College of Pharmacy, Shirur, Pune – 412 210, IN
2 SCSSS's Sitabai Thite College of Pharmacy, Shirur, Pune – 412 210, IN
3 Sinhgad College of Pharmacy, Vadgaon (Bk.), Pune – 411 041, IN

Abstract

Recent technological advancements have been made in controlled oral drug delivery systems by overcoming physiological difficulties, such as short gastric residence time and highly variable gastric emptying time. Several technical approaches are currently utilized in the prolongation of gastric residence time, including high density, swelling and expanding, polymeric mucoadhesive, ion-exchange, raft forming, magnetic and floating drug delivery systems, as well as other delayed gastric emptying devices. The purpose of this review on floating drug delivery systems (FDDS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. In this review, the current technological developments of FDDS including patented delivery systems and marketed products, and their advantages and disadvantages. The review also aims to discuss various parameters affecting the behavior of floating and swelling multiparticulate in oral dosage form summarizes the in vitro techniques, in vivo studies to evaluate the performance and application of floating and swellable systems, and applications of these systems. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form.

Keywords

Floating Drug Delivery System, Gastroretentive Drug Delivery System, Hydrodynamically Balanced System, Evaluation Parameterin Vivo, In Vitro.

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